A Systematic Investigation for the Preparation of a Novel Polycyclic [6.6.5], [6.6.6], [6.6.7.6] & [6.7.5] Ring Systems by Reductive Cyclization With Lah by Venugopal Rao Veeramaneni

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A SYSTEMATIC INVESTIGATION FOR THE PREPARATION OF A NOVEL POLYCYCLIC [6.6.5], [6.6.6], [6.6.7.6] & [6.7.5] RING SYSTEMS BY REDUCTIVE CYCLIZATION WITH LAH Discovery Research 05/01/2004 Venugopal Rao Veeramaneni 1 Reduction & Reagents For Reduction Reduction is defined in chemistry as loss of oxygen, gain of hydrogen or gain of electrons. A reducing agent is the substance which donates electrons in an oxidation-reduction reaction. (A reducing agent is easily oxidized) In 1862 first reducing
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  1   DiscoveryResearch 05/01/2004 A SYSTEMATIC INVESTIGATION FOR THEA SYSTEMATIC INVESTIGATION FOR THEPREPARATION OF A NOVEL POLYCYCLICPREPARATION OF A NOVEL POLYCYCLIC  [6.6.5], [6.6.6], [6.6.7.6] & [6.7.5]  [6.6.5], [6.6.6], [6.6.7.6] & [6.7.5]  RING SYSTEMSRING SYSTEMSBY REDUCTIVE CYCLIZATION WITHBY REDUCTIVE CYCLIZATION WITHLAHLAH Venugopal Rao VeeramaneniVenugopal Rao Veeramaneni    2 Reduction & Reagents For ReductionReduction & Reagents For Reduction Reduction is defined in chemistry as loss of oxygen, gain of hydrogenReduction is defined in chemistry as loss of oxygen, gain of hydrogenor gain of electrons.or gain of electrons.A reducing agent is the substance which donates electrons in anA reducing agent is the substance which donates electrons in anoxidation-reduction reaction. (A reducing agent is easily oxidized)oxidation-reduction reaction. (A reducing agent is easily oxidized)ãInIn18621862first reducing conditions Zn/acetic acid, Sodiumfirst reducing conditions Zn/acetic acid, Sodiumamalgam/acetic acid, Sodium in toluene/acetic acid or Iron/acetic acid.amalgam/acetic acid, Sodium in toluene/acetic acid or Iron/acetic acid.ãInIn19031903Sodium/ethanol for reduction was discovered bySodium/ethanol for reduction was discovered by ManichManich andand   Bouveault & Blank  Bouveault & Blank  ..ãInIn19251925aluminum ethoxide byaluminum ethoxide by VerlyVerly && MeerweinMeerwein and inand in19261926 aluminum isopropoxide byaluminum isopropoxide by  Ponndorf. Ponndorf.  ãInIn19391939  DiboraneDiborane , in, in19421942  NaBH4NaBH4 , in, in19451945  LAHLAH were discoveredwere discovered by by  H. I. Schlesinger  H. I. Schlesinger  ..  3 Reductive Cyclization withReductive Cyclization with L A HL A H NSOR NSOOO NSO LAHLAH      X LAHLAH NSOH  4 OptimizationOptimization S.No.LAHeq.Ratio of products (%)   S.MCyclicAlcohol1 0.560400 2 1.04960 3 1.101000 4 2.00970 5 4.00919 6 6.007228
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