Effects of Omega-3 Fatty Acids on Aging, Dementia and Neurological Diseases

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Evidence Report/Technology Assessment Number 114 Effects of Omega-3 Fatty Acids on Cognitive Function with Aging, Dementia, and Neurological Diseases Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.gov Contract No. 290-02-0003 Prepared by: Southern California/RAND Evidence-based Practice Center, Los Angeles, CA Catherine H. MacLean, MD, PhD Task Order Director
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     Evidence Report/Technology Assessment Number 114 Effects of Omega-3 Fatty Acids on CognitiveFunction with Aging, Dementia, and NeurologicalDiseases Prepared for: Agency for Healthcare Research and QualityU.S. Department of Health and Human Services540 Gaither RoadRockville, MD 20850www.ahrq.gov Contract No. 290-02-0003Prepared by :Southern California/RAND Evidence-based Practice Center, Los Angeles, CA Catherine H. MacLean, MD, PhD Task Order Director  Amalia M. Issa, MPH, PhDWalter A. Mojica, MD, MPH   Scientific Reviewers Sydne J. Newberry, PhD  Editor  Sally C. Morton, PhDPaul G. Shekelle, MD, PhD Program Directors Lara G. Hilton, BA   Programmer/Analyst  Rena Hasenfeld Garland, BA Project Manager  Jessie McGowan, MLISNancy Santesso, RD, MLIS    Librarians Shannon Rhodes, MFACony Rolon, BAShana Traina, MA   Staff Assistants  AHRQ Publication No. 05- E011-2February 2005   This report may be used, in whole or in part, as the basis for development of clinical practiceguidelines and other quality enhancement tools, or a basis for reimbursement and coveragepolicies. AHRQ or U.S. Department of Health and Human Services endorsement of suchderivative products may not be stated or implied.AHRQ is the lead Federal agency charged with supporting research designed to improve thequality of health care, reduce its cost, address patient safety and medical errors, and broaden accessto essential services. AHRQ sponsors and conducts research that provides evidence-basedinformation on health care outcomes; quality; and cost, use, and access. The information helpshealth care decisionmakers—patients and clinicians, health system leaders, and policymakers—make more informed decisions and improve the quality of health care services.   iiThis document is in the public domain and may be used and reprinted without permission exceptthose copyrighted materials noted for which further reproduction is prohibited without thespecific permission of copyright holders. Suggested Citation: MacLean CH, Issa AM, Newberry SJ, Mojica WA, Morton SC, Garland RH, Hilton LG, TrainaSB, Shekelle PG. Effects of Omega-3 Fatty Acids on Cognitive Function with Aging, Dementia,and Neurological Diseases. Evidence Report/Technology Assessment No. 114 (Prepared by theSouthern California Evidence-based Practice Center, under Contract No. 290-02-0003.) AHRQPublication No. 05-E011-2. Rockville, MD. Agency for Healthcare Research and Quality.February 2005.   iii Preface The Agency for Healthcare Research and Quality (AHRQ), through its Evidence-BasedPractice Centers (EPCs), sponsors the development of evidence reports and technologyassessments to assist public- and private-sector organizations in their efforts to improve thequality of health care in the United States. This report on Effects of Omega-3 Fatty Acids onCognitive Function with Aging, Dementia, and Neurological Diseases was requested and fundedby AHRQ . The reports and assessments provide organizations with comprehensive, science-based information on common, costly medical conditions and new health care technologies. TheEPCs systematically review the relevant scientific literature on topics assigned to them byAHRQ and conduct additional analyses when appropriate prior to developing their reports andassessments.To bring the broadest range of experts into the development of evidence reports and healthtechnology assessments, AHRQ encourages the EPCs to form partnerships and enter intocollaborations with other medical and research organizations. The EPCs work with these partnerorganizations to ensure that the evidence reports and technology assessments they produce willbecome building blocks for health care quality improvement projects throughout the Nation. Thereports undergo peer review prior to their release.AHRQ expects that the EPC evidence reports and technology assessments will informindividual health plans, providers, and purchasers as well as the health care system as a whole byproviding important information to help improve health care quality.We welcome comments on this evidence report. They may be sent by mail to the Task OrderOfficer named below at: Agency for Healthcare Research and Quality, 540 Gaither Road,Rockville, MD 20850, or by email to epc@ahrq.gov. Carolyn M. Clancy, M.D.DirectorAgency for Healthcare Research and QualityPaul M. Coates, Ph.D.Director, Office of Dietary SupplementsNational Institutes of HealthJean Slutsky, P.A., M.S.P.H.Director, Center for Outcomes and EvidenceAgency for Healthcare Research and QualityKenneth S. Fink, M.D., M.G.A., M.P.H.Director, EPC ProgramAgency for Healthcare Research and QualityBeth A. Collins-Sharp, R.N., Ph.D.EPC Program Task Order OfficerAgency for Healthcare Research and QualityThe authors of this report are responsible for its content. Statements in the report shouldnot be construed as endorsement by the Agency for Healthcare Research and Quality orthe U.S. Department of Health and Human Services of a particular drug, device, test,treatment, or other clinical service.
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