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NSAIDs-III Dr.U.P.Rathnakar MD.DIH.PGDHM 1 ARACHIDONIC ACID Cyclooxygenase-1 [Constitutive-Good???] Cyclooxygenase-2 [Induced-Bad???] ADEs NSAIDs Uses PGs -Gastro protective -Platelet function -Renal function -Uterine contractions -Inflammation -Fever -Pain 2 Classification-NSAIDs ã Nonselective Irreversible inhibitors of COX Aspirin ã Nonselective reversible inhibitors of COX Ibuprofen, Diclofenac, Indomethacin, Piroxicam ã Weak inhibitors of COX1 Nimesulide ã Preferential inhibitors
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  NSAIDs-III Dr.U.P.Rathnakar MD.DIH.PGDHM 1  ARACHIDONIC ACIDPGsCyclooxygenase-1 [Constitutive-Good???] Cyclooxygenase-2 [Induced-Bad???] NSAIDs ADEs Uses -Gastro protective-Platelet function-Renal function-Uterine contractions   -Inflammation-Fever-Pain   2  Classification-NSAIDs ã Nonselective Irreversibleinhibitors of COX Aspirin ã Nonselective reversibleinhibitors of COXIbuprofen, Diclofenac,Indomethacin, Piroxicam ã Weak inhibitors of COX1Nimesulide ã Preferential inhibitors ofCOX-2[>10times]Meloxicam,Nabumetone,Etodolac ã Selective reversibleinhibitors of COX-2[>50times]Rofecoxib, Celecoxib,Valdecoxib, Etoricoxib,Parecoxib ã Inhibitors of COX-3[?]or hypothalaamic COX-1inhibitors Paracetamol, Analgin ã NSAIDs – Not inhibitorsof COXNefopam, Diacerein 3  NSAIDs-Common benefits and ADEs Beneficial effects ã Analgesic ã Anti-inflammatory ã Antipyretic ã Antithrombotic ã Closure of D.A.-new born Toxicities ã Gastric ulcer ã GI bleed ã Nephropathy ã Delay in labour ã Hypersensitivity ã Premature closure of D.A. 4
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