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Name OXACILLIN Classification Penicillins Action A penicillinase – resistant penicillin that inhibits cellwall synthesis during microorganism multiplication; bacteria resists penicillins by producing penicilllinase – enzymes that convert penicillins to inactivate penecillic acids. Oxacillin resists these enzymes Indications Systemic infections caused by penicillinaseproducing staphylococci Adverse reactions Common: Thrombophebitis Uncommon: Neuropathy, neuromuscular irritability, lethargy, h
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  Name Classification Action Indications Adverse reactions Nursingconsiderations OXACILLIN Penicillins    A penicillinase –  resistant penicillinthat inhibits cell- wall synthesisduringmicroorganismmultiplication; bacteria resistspenicillins by producingpenicilllinase –  enzymes thatconvert penicillinsto inactivatepenecillic acids.Oxacillin resiststhese enzymes   Systemic infectionscaused by penicillinase-producingstaphylococci   Common: Thrombophebitis  Uncommon : Neuropathy,neuromuscular irritability,lethargy, hallucination,anxiety, confusion,agitation, depression,dizziness, fatigue, orallesions, nausea, vomiting,diarrhea, enterocolitis,interstitial nephritis,nephropathy,thrombocytopenia,hemolytic anemia, anemia,hypersensitivity reactions      Usecautiously inpatients withother drugallergy,especially tocephalosporins.      Obtainspecimen forculture andsensitivity tests beforefirst dose.      To prevent veinirritation,avoidcontinuousinfusions.Change siteevery 48hours.      Give 1-2hours beforeor 2-3 hoursafter meals toprevent  gastricirritation.  
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