The Role of the Tap Protein in the Immune Response 605

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TAP ogy/Students/spring20 00/buxton/MFIP.htm   = Transporter associated with antigen processing. ABC Subfamily B.  2 units – TAP1 and TAP2 = heterodimer. 10 TM helices 9 TM helices Located in ER membrane due to signals in the transmembrane region.  Mechanism 1. Peptide binds Cytosol ER 2. ATP binds + hydrolyses ATP ADP Cytosol ER Pi Fast! High Affinity Slow Conformational Change 2nd Conformational Change Translocation of peptide Typ
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    TAPTAP  = Transporter associated with antigen= Transporter associated with antigenprocessing.processing.  ABC Subfamily B.ABC Subfamily B.     2 units – TAP1 and TAP2 =2 units – TAP1 and TAP2 =heterodimer.heterodimer.10 TM helices 9 TM helices10 TM helices 9 TM helices  Located in ER membrane due to signals inLocated in ER membrane due to signals inthe transmembrane region.the transmembrane region.    MechanismMechanism 1. Peptide binds Fast! HighAffinitySlow ConformationalChange 2. ATP binds +hydrolyses ATP   PiADP 2 nd ConformationalChange Translocation of peptide CytosolERCytosolER    Type 1 MHCsTy   pe 1 MHCs  Found on all body cells.Found on all body cells.  Present endogenous peptides toPresent endogenous peptides toimmune system.immune system.  Bind to cytotoxic CD8+ T-cells.Bind to cytotoxic CD8+ T-cells.  Assembled in the ER, to form largeAssembled in the ER, to form largemacromolecular loading complex whichmacromolecular loading complex whichincludes TAP.includes TAP.  Cytotoxic T-cells not activated in nonCytotoxic T-cells not activated in noninfected state due to elimination duringinfected state due to elimination duringdevelopment in the thymus.development in the thymus. of  Biology  , 5th editionCampbell, Reese, and Mitchell
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