The (short) story of brucellosis in western Kenya

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1. The (short) story of brucellosis in western KenyaWill de Glanvillewww.zoonotic-diseases.orgCentre for Immunity, Infection and Evolution, University of…
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  • 1. The (short) story of brucellosis in western KenyaWill de Glanvillewww.zoonotic-diseases.orgCentre for Immunity, Infection and Evolution, University of EdinburghandInternational Livestock Research Institute, NairobiWorkshop: An Integrated Approach to Controlling Brucellosis in Africa, AddisAbaba, 29-31 January 2013
  • 2. A lateral flow assay was used as primary screening test for brucellosisin sympatric animals and people.- Rapid and simple- Good performance- Animal and human tests- A bit expensive
  • 3. 2116 people in 416 homesteadsLFA : 0.71% (95% C.I. 0.38 – 1.17)RBT : 0.06% (95% C.I. 0.0014 – 0.32)No relationship between animal and human sero-status at the household levelWe found:893 cattle in 230 homesteadsLFA : 0.31% (95% C.I. 0.06 – 0.89)
  • 4. Further surveillance based on central point samplingSeroprevalence based on RBT < 0.5%
  • 5. But, brucellosis apparently a common diagnosis in district andsub-district hospitals in study area....
  • 6. So, we went to investigate.Rose BengalBrucella Agglutination TestLateral Flow Assay+ve
  • 7. A population of 827brucellosis suspects
  • 8. A population of 827brucellosis suspectsBAT: 19.7%
  • 9. A population of 827brucellosis suspectsRBT: 0.6%
  • 10. 5% of reactive BATconfirmed on LFA
  • 11. So, brucellosis appears to be rare and over-diagnosed usingcurrent diagnostic approaches in western Kenya.Limits use of people as ‘sentinels’ for zoonotic disease inanimals......‘one-health’
  • 12. Thank you.Eric Fèvre eric.fevre@ed.ac.ukWill de Glanville w.a.de-glanville@sms.ed.ac.ukwww.zoonotic-diseases.org
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